Executive Summary
Scalpel Ventures, a healthcare-focused venture capital firm co-founded by orthopedic surgeon Dr. Selene Parekh and financial entrepreneur Saket Jain, sought to avoid the pitfalls of traditional VC fund structures. Emerging managers often face intense pressure to raise and deploy capital quickly, leading to rushed investment decisions and reduced flexibility.
By leveraging Avestor’s Customizable Fund® model, Scalpel Ventures designed a fund that allows patient, deal-by-deal investing under a single fund umbrella. Investors benefit from transparency and control, choosing which deals to participate in, while the fund managers gain the freedom to focus on quality, not speed. This structure has already enabled investments in pioneering companies such as Oxford Performance Materials and Artelon, producing strong returns and validating the model.
The partnership between Selene and Saket combines deep medical insight with financial and operational expertise, creating a powerful balance for evaluating healthcare startups. Scalpel Ventures’ experience demonstrates how a Customizable Fund® empower emerging managers to build high-quality portfolios, align more closely with LPs, and transform industries with thoughtful, long-term capital deployment.
Background: A New Kind of Healthcare Venture Fund
Scalpel Ventures is an emerging venture capital firm specializing in healthcare innovation – particularly in musculoskeletal care and related medical technologies. The firm was co-founded by Dr. Selene Parekh, a renowned orthopedic surgeon with 20+ years of clinical innovation (holding over 10 medical patents), and Saket Jain, a tech entrepreneur and investor with two decades of business scaling experience. This unique partnership fuses deep medical domain expertise with financial and operational acumen. Dr. Parekh’s medical background and Saket’s financial/entrepreneurial background make them ideal partners, enabling informed investment decisions that balance clinical impact with business viability.
From the outset, Scalpel Ventures’ mission has been clear: to transform healthcare through strategic investments in groundbreaking startups. The firm focuses on visionary companies tackling complex healthcare challenges
For example, advanced orthopedic implants, regenerative medicine, and musculoskeletal therapies that improve patient outcomes. What truly sets Scalpel Ventures apart, however, is not just its niche focus or expert team, but the innovative fund model it chose in order to better serve both its portfolio companies and investors.
Launching a new venture fund is notoriously challenging for emerging managers. In a traditional VC fund model, managers must typically raise a large pool of capital upfront and are then under pressure to deploy that capital quickly (often within a few years) to meet investor expectations and the fund’s mandated timeline. This model can introduce several problems:
For Scalpel Ventures, which values deep due diligence and picking only the best healthcare startups, these traditional constraints were a serious concern. Dr. Parekh and Saket Jain did not want the typical pressure of “use it or lose it” with investor capital. They preferred an open-ended approach, where they could take their time to research companies thoroughly, invest selectively, and deploy capital gradually as truly compelling opportunities arose. The challenge was to find a fund structure that allowed this patient, quality-driven strategy while still attracting investors.
Scalpel Ventures found its solution with Avestor’s Customizable Fund® platform, adopting an innovative fund model that perfectly aligned with their needs. Avestor’s Customizable Fund® is essentially a hybrid between a traditional blind-pool fund and deal-by-deal investing. It allowed Scalpel Ventures to create a single fund umbrella under which they can raise capital and execute multiple investments, but with a crucial twist – investors can choose which specific deals they participate in.
Key features of this model include:
By using Avestor’s platform to implement this Customizable Fund®. Scalpel Ventures essentially engineered a fund that operates on their terms. It gave them the structural flexibility to honor their careful, research-driven investment approach while still providing a clear framework for investors to participate. Avestor also provided a ready-made infrastructure: an investor portal and back-end fund administration, so the Scalpel team could focus on evaluating startups rather than paperwork.
With the Customizable Fund® in place, Scalpel Ventures began sourcing and vetting deals in their specialty domain. The investment approach adopted is highly selective: “Each opportunity we present is evaluated by our experienced team, ensuring that we only bring forward companies with the potential to drive meaningful change and deliver significant returns.”
On the investor side, Scalpel communicates each opportunity through Avestor’s platform, providing full information and updates. Investors can review the details of a given startup (market, product, team, terms, etc.) and then decide to allocate part of their committed capital to that deal. If an investor prefers to skip a particular deal, they simply keep their capital un-deployed until the next opportunity – a level of granularity not possible in a traditional fund.
Early results have been very promising. Within a few months of launch, Scalpel Ventures closed its first investment deal under this model, raising a significant round for a groundbreaking company utilizing 3D printing technology to create personalized implants. This company, Oxford Performance Materials (OPM), exemplified the kind of high-impact
innovation Scalpel seeks. OPM’s proprietary 3D-printed orthopedic implants attracted Dr. Parekh’s interest immediately – in fact, he personally had collaborated with OPM and even performed the world’s first surgery using their implant, validating its medical value. By leveraging the Customizable Fund®. Scalpel was able to quickly mobilize capital from its LPs to invest in OPM’s round.
Beyond OPM, Scalpel’s team continues to carefully build a diversified portfolio in the healthcare sector. They have already seen noteworthy successes. One example is Artelon, a regenerative medicine company in orthopedic implants – an investment that yielded a 5× return in just 11 months for Scalpel’s team. Another is Paragon 28, a musculoskeletal-focused company that went to a successful IPO, demonstrating the kind of high-upside opportunities Scalpel targets.
Adopting Avestor’s Customizable Fund® structure has yielded clear benefits for Scalpel Ventures and its stakeholders:
The partnership of a medical expert and a finance expert is somewhat uncommon in venture funds, and it has paid dividends. Dr. Selene Parekh’s deep medical knowledge means Scalpel can rigorously assess the clinical merit and market need of healthcare innovations. Meanwhile, Saket Jain’s business and fundraising expertise ensures that the fund’s operations are sound and that portfolio companies receive guidance on scaling and strategy.
This balance reduces risk: Scalpel leverages insider knowledge to minimize risks and deliver substantial returns. For example, when evaluating OPM’s 3D-printed implants, Dr. Parekh understood the surgical value and unmet need, while Saket could evaluate the company’s business model and plan the investment terms. Startups see value in this combination as well – portfolio founders know that beyond capital, Scalpel brings connections in the medical community, clinical trial insights, and seasoned business mentorship.
Scalpel Ventures’ experience illustrates how an innovative fund structure can solve the classic challenges faced by new venture managers. By adopting Avestor’s Customizable Fund® model, Dr. Selene Parekh and Saket Jain built a healthcare-focused VC fund that aligns with their philosophy: patient, high-conviction investing in game-changing startups. They successfully avoided the trap of rushing investments, without sacrificing growth – in fact, they accelerated it.
This case study highlights several key takeaways for the venture capital industry:
Scalpel Ventures demonstrates that when you remove the artificial pressures and align incentives properly, venture capital can truly focus on what matters most: finding and funding the best innovations that will transform industries and improve lives.
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